DARE-RUSSI SARCOID ( J. Darier , fr. dermatologist, 1856 — 1938; G. Roussy, fr. pathologist and neurologist, 1874 — 1948; a synonym hypodermic sarcoids to Darya — Rusey) - seldom found damage of skin in the form of subcutaneously the located deep painless nodes. It is described in 1904 to Zh. Darya and G. of Russia.
the Aetiology and nosological accessory of D. — R. pages are not quite clear and are a subject of numerous discussions that becomes complicated a rarity of reliable observations. In 20 — the 30th 20 century the view of D. — R. by page as was extended to a kind of the condensed Bazen's erythema, i.e. as to a dermatosis of a tubercular etiology; further L. A. Neradov (1956), Hans and Shteygleder adhered to this look (O. of Gans, G. To. Steigleder, 1955), Funk (Page F. Funk, 1959), etc. According to other authors, D. — R. the page represents peculiar, not tubercular etiology, the granuloma developing in hypodermic cellulose.
A number of modern writers considers D. — R. page as a deep form of sarcoid of Beck, therefore, as manifestation of a general disease — sarcoidosis (see); this opinion was for the first time expressed to Zh. Darya in 1934 and found reflection in the guides to dermatology 60 — the 70th there are 20 century; it is based on observations of a combination of D. — R. by page with other manifestations of a sarcoidosis on skin and in other bodies.
Carried to a sarcoidosis the so-called disseminated and knotty sarcoids to Darya earlier, but, apparently, as well as assumed. To Darya (1909), they are not ulcerating kind of the condensed Bazen's erythema (see. Tuberculosis cutis ).
Patogistologiya in typical cases — the so-called sarkoidny granuloma which is characterized by a combination epithelioid, lymphoid and a small amount of colossal cells without the phenomena of a caseous necrosis.
The clinical picture
D.'s Current — R. of page chronic, is more rare subacute. The consistence of nodes dense, spherical shape, is more rare ovoidny, the size — from 1 to 3 hardly in dia. Nodes are located separately, the quantity them can reach several tens; sometimes, merging with each other, nodes form the big convex centers of uneven outlines to dia, to 15 — 20 cm. Nodes do not ulcerate, the skin covering them can be soldered to them, color its light pink, dim pink, sometimes a pink and reddish shade. There is no favourite localization of nodes, slightly more often they are located on side surfaces of a trunk, on a breast and hips, usually symmetrically. The general condition of patients, as a rule, remains satisfactory, nodes are almost painless.
the Diagnosis is established on the basis by a wedge, pictures and patogistol. data. The differential diagnosis is carried out with knotty vasculites (see. Vasculitis of skin ), with similar manifestations leprosies (see), tuberculosis (see. Tuberculosis cutis ), syphilis (see), and also with the nodes which are formed after subcutaneous injections of oil drugs (see. Lipogranuloma ) and insulin.
Corticosteroid drugs (Prednisolonum, dexamethasone) inside within 6 — 8 months; usually begin with 30 — 40 mg of Prednisolonum a day with the subsequent dose decline by the standard rules.
Forecast concerning life favorable; without treatment nodes exist for many years; prolonged treatment by corticosteroids not always leads to their involution.
Bibliography: Neradov L. A. To a question of clinical displays of an indurative tuberculosis cutis, Nauch. zap. Gorkovsk. in-that dermas, and veins., century 17, page 93, 1956, bibliogr.; P and e of N of A. S. A sarcoidosis — the case record and dermatological aspects of a problem, Vestn, dermas, and veins., No. 1, page 34, 1961; about N e, the Sarcoidosis, M., 1964, bibliogr.; Darier J. et Roussy G. Un cas de tumeurs bGnignes multiples (sar-coides sous-cutan6es ou tuberculides nodu-laires hypodermiques), Bull. Soc. franc. Derm. Syph., t. 15, p. 54, 1904; I of g a n g S. Darier — Roussy’s sarcoid, Dermatologica (Basel), v. 119, p. 300, 1959; Lebacq E. La sarcoidose de Besnier — Boeck — Schau-mann, Bruxelles, 1964, bibliogr.