From Big Medical Encyclopedia

CYTOLYSIS (cytolysis; Greek kytos a receptacle, here — a cell + lysis decomposition, dissolution) — full or partial dissolution of structural components of a cell under the influence of hydrolases.

C. is the final stage of death of a cell, it is characterized by destruction of its membrane structures and hydrolytic fusion of cytoplasm. C. usually the coagulative necrosis of cytoplasm with the subsequent its disintegration on glybk (plasmorrhesis) precedes. Quite often C. only a part of a cell (a focal kollikvatsion-ny necrosis, or balloon dystrophy) is exposed. In development of C. disturbances of permeability of membranes and damage of nuclear structures have the leading value. Results gistokhy. and biochemical researches confirm disturbance of exchange processes in cells, decrease and the termination of oxidizing phosphorylation and increase in activity of hydrolases. At electronic microscopic examination in structures of a cell the phenomena of hypostasis and swelling, an enlightenment and consolidation of a matrix, disappearance of granules of a glycogen and destruction of membrane educations are noted.

In a crust, time the term «cytolysis» is used seldom since the structural changes in cells which are observed at this process carry to an autolysis (see), to-ry reflects as the phenomena of physiological destruction, and morfol. the changes arising at patol. processes (see the Necrosis).

Bibliography: L at sh N and to about in E. F. and Sha-piron. A. Autoliz, M., 1974; The General pathology of the person, under the editorship of A. I. Struko-va, etc., page 116, M., 1982; Strukova. And. and With e r about in V. V. Pathological anatomy, page 51, M., 1979.

G. M. Mogilevsky.