CREATINURIA (creatine + grech, wetting uron) — release of creatine with urine. Creatine is found in urine when its concentration in plasma exceeds 1,6 mg of %, i.e. at a hypercreatinemia (see. Creatinemia ). At loading creatine — reception in a dose of 1,32 g — its allocation with urine makes apprx. 30% of the accepted quantity (the test of tolerance to creatine).
Definition of creatine in urine is based that at high temperature and in the presence of salt to - you it turns into creatinine which is found on emergence of orange coloring at its mixing with alkaline picrate (see. Jaffe reaction ).
Allocate fiziol. To., edges it is quite often observed at children, at women during pregnancy or a lactation, at the excess use of meat, fish, a liver, and also patol. To., caused by excess formation of endogenous creatine at the increased disintegration of proteins or disturbance of its exchange (see. Creatine ). Patol. To. it is observed at patients with the progressing muscular dystrophy, at a myasthenia, miozita, a hyperthyroidism, an acromegalia, an addisonovy disease, Itsenko's disease — Cushing, a diabetes mellitus, at damages of a liver, nephrite, a pseudorheumatism, myoglobulinemia, intestinal impassability, at heavy cardiovascular insufficiency, and also at exhaustion, avitaminosis of E and S, at treatment by glucocorticoid hormones. At diseases of muscular system (primary or secondary) there is a disturbance of exchange of creatine and its hemimetaboly in creatinine therefore the number of the last in blood and urine decreases, and the level of creatine in plasma, on the contrary, increases, there are a hypercreatinemia and
K. K. was considered as one of precursory symptoms of the progressing muscular dystrophy. However quite frequent identification To. at other diseases points out not specificity of this symptom and demands conducting additional diagnostic testings.
Bibliography: Kalinin A. P., Agafonov B. V. and About d and N about to about in and V. A. Myopathies at a disease of some hemadens, Owls. medical, No. 6, page 44, 1976; Mosquitoes F. I., Korovkin B. F. and the M e N sh and to about in V. V. Biochemical researches in clinic, page 133, L., 1976; The Guide to clinical laboratory trials, under the editorship of E. A. Kost and L. G. Smirnova, page 215, M., 1964; Todorov Y. Clinical laboratory trials in pediatrics, the lane with bolg., page 169, Sofia, 1968.
B. V. Konyaev.