COTARNINE (Cotarninum) — hemostatic. In the USSR chloride is applied cotarnine, Cotarnini chloridum (synonym: Stypticinum, Oxystyptin, Styptogen; GFH, joint venture. B) — uterine and hemostatic. 2 Methyl - 6, 7 - metilendioks - 8 - metoksi-3, 4-digidroizokhinoliny chloride, C 12 H 14 ClNO 3 • nH 2 O:
Light yellow crystal powder, inodorous, bitter taste. It is hygroscopic, we will very easily dissolve in water and it is easy in 95% alcohol. Water solutions with pH 4,5 — 5,2 will sterilize at 100 ° within 30 min.
Has tonic effect on muscles of a uterus and other internals. On character pharmakol, actions it is similar to drugs of an ergot — ergometrine (see), ergotamine (see), but on activity considerably concedes to them.
It is applied at subinvolution of a uterus after abortions and childbirth, at the menorrhagias and uterine bleedings which are not connected with disturbances of a cycle (e.g., at inflammatory processes or myoma).
Appoint inside 0,05 g 3 times a day or in the form of 2 — 5% of solution on 1 ml under skin. Sometimes apply to a stop of bleeding locally in the form of 1 — 2% of solution. The highest doses for adults inside: one-time 0,1 g, daily 0,3 g.
Forms of release: powder and tablets, coated, on 0,05 g. Keep in well corked banks of orange glass in the place protected from light.
See also Uterine means .
V. K. Muratov.