COOK Robert

From Big Medical Encyclopedia

COOK Robert (Cooke Robert, 1880 — 1960) — the American allergist, one of founders of theoretical, experimental and practical allergology in the USA, the doctor of medicine (1904), the first president of the American society of allergists (1924).

KUK Robert

In 1904 left medical college Colombian un-that. Since 1905 worked in hospitals of New York. In 1920 — 1932 the assistant to department of immunology, and from 1932 to 1940 the assistant to department of internal medicine in Kornelskom un-those. In 1949 — 1960 the director in-that allergies of Hospital of Roosevelt in New York.

R. Cook published the St. 180 scientific works devoted to hl. obr. to various questions of allergology. He developed (1916) practical bases of the method of specific decrease in hypersensitivity (desensitization) offered in 1911 by L. Noon at allergic diseases and a method of standardization of extracts diagnostic and to lay down. allergens on units of protein nitrogen (PNU-protein nitrogen unit); together with Coca (A. F. Sosa) offered the term «atopy» for designation of group of allergic diseases (1923) in which development the importance has hereditary predisposition to a disease; divided (1930) all allergic reactions to two big groups — reactions of the immediate and slowed-down types. In 1935 Cook established that blood serum of patients pollinosis (see), treated by method of specific desensitization, possesses to lay down. action concerning patients with forms of a pollen allergy, similar on an etiology. He explained this phenomenon with existence in serum of the specific antibodies called by it the blocking (protective) or overwhelming antibodies, which on physical. - chemical and biol, to properties, and also on the mechanism of education differ from the skin sensibilizing antibodies markedly (see. Desensitization ).

Studying questions of a polyvalent sensitization to many types of pollen of trees, herbs and flowers, it showed (1940) a possibility of reaction of allergic antibodies with many related allergens. R. Cook established that at an atopy and an idiosyncrasy decrease in skin sensitivity and a condition of immunity do not arise in parallel to one another as it is noted at a serumal allergy (1943).

Works: Human sensitization, J. Immunol., y. 1, p. 201, 1916 (sovm, with Veer A. V.); Allergy in drug idiosyncrasy, J. Amer. med. Ass., v. 73, p. 759, 1919; Classification of phenomena of hypersensitiveness, J. Immunol., y. 8, p. 163, 1923 (sovm, with Coca A. F.); Delayed type of allergic reaction, Ann. intern. Med., v. 3, p. 658, 1930; Serological evidence of immunity with coexisting sensitization in a type of human allergy, J. exp. Med., v. 62, p. 733, 1935 (sovm, with other); Allergy in theory and practice, Philadelphia — L., 1947; The antibody mechanisms of ragweed allergy, J. exp. Med., v. 101, p. 177, 1955; Int. Arch. Allergy, v. 17, p. 129, 1960 (sovm, with other).

Bibliography: Ado A. D. General allergology, page 10, M., 1978; Excerpts from classics in allergy, ed. by M. Samter, p. 52, Columbus, 1969.

Yu. L. Guly.