From Big Medical Encyclopedia

COACERVATION (Latin coacervatio collecting, accumulation) — the process having extremely important all-biological value and representing division of solutions of high-molecular substances, and also colloidal solutions into two liquid phases: enriched (I) and grown poor (II) macromolecules or colloid particles. The phase I results from association of macromolecules in solutions of high-molecular substances or colloid particles in colloid solutions usually in microscopic drops to dia. 0,5 — 640 microns. This phase, in a cut the ground mass of solute is concentrated, call a coacervate. The phase II representing almost pure dispersion medium is called equilibrium liquid. The coacervate together with equilibrium liquid is called coacervate system.

The founder of the doctrine about To. both coacervates and their role in biology the Dutch scientist Byungenberg de H. G. Bungenberg de Jong is. According to A. I. Oparin's theory, at emergence of life isolation of belkovopodobny supramolecular complexes from waters of primary ocean happened on Earth by formation of coacervate drops. Coacervate drops are considered according to this theory as one of precellular models.

As a result To. in water solutions of proteins, enzymes, nucleinic to - t, carbohydrates, lipids with participation of alkaloids, antibiotics, amino acids, dyes, quinones, salts, etc., and also in cytoplasm and biol, liquids are formed the coacervate systems which are used in pharmacology at production of drugs in the textile industry etc.

See also Life .

Bibliography: Evreinova T. N. Concoction of substances and effect of enzymes in coacervates, M., 1966, bibliogr.; Oparin A. I. Life, its nature, origin and development, M., 1968, bibliogr.; Serebrovskaya K. B. Coacervates and protoplasm, M., 1971, bibliogr.; Bungenberg de Jong H. G. La coacervation et son importance en biologie, t. 1—2, P., 1936.

T. H. Evreinova.