CLOFIBRATUM (Clofibratum, synonym: Atromidinum, Miscleronum, Amotril, Atromid S, Chlorophenisate, Elpi, Lipavlom, Neo-Atromid, Regelan) — synthetic drug of hypolipidemic action. Ethyl-alpha (steam-hlorfenoksi) - isobutyrate:
Light yellow liquid with a slight aromatic smell. It is water-insoluble, alcohol-soluble, ether and other organic solvents. Drug effectively reduces the level of triglycerides in a blood plasma, reducing formation of lipoproteids of very low density rich with triglycerides — pre - beta lipoproteids, and at the same time accelerates a catabolism already formed pre - beta lipoproteids; also decrease in level of the intermediate lipoproteids (on the way of transformation pre - beta lipoproteids in beta lipoproteids) collecting in a blood plasma at some patol, states is observed.
Action To. on beta lipoproteids, the richest with cholesterol and consequently, and on cholesterol does not submit to strict patterns: both decrease, and increase in their content in blood can be observed. In this regard To. apply, first of all, to treatment of the giperlipidemichesky states connected with accumulation in blood pre - beta lipoproteids (the IV type of a giperlipoproteidemiya), and intermediate, «pathological», lipoproteids (the III type of a giperlipoproteidemiya). In some cases the noticeable hypolipidemic effect at purpose of drug is marked by the patient from IIB the type of a giperlipoproteidemiya which is characterized by increase in blood both pre-beta and beta lipoproteids. At the V type of a giperlipoproteidemiya which is characterized by increase in blood not only pre - beta lipoproteids, but also chylomicrons, drug is ineffective and absolutely inefficient at the I type of a giperlipoproteidemiya (hyper chylomicronemia).
To. appoint inside 1,5 — 2 g a day, usually in two steps. Treatment is carried out it is long — courses for 20 days with breaks in 20 — 30 days (4 — 6 courses). At patients with III and the IV type of a giperlipoproteidemiya the level of triglycerides in blood under the influence of drug decreases by 30 — 40%, and at a combination of drug to a dietotherapy in a bigger degree. At the same time the rassasyvaniye of xanthomas, reduction of frequency of attacks of stenocardia, improvement of the general state is observed.
To., as a rule, it is well transferred by patients; nausea, vomiting, a diarrhea, skin rashes, a hamaturia, dysuric frustration, a miositis are in rare instances noted: increase of body weight and change of a picture of blood (anemia, a leukopenia, an eosinophilia) is possible. To. we oppress coagulant system of blood and strengthens effect of anticoagulants. Therefore at combined use of drug with anticoagulants the dose of the last is reduced and carry out treatment under careful control of maintenance of a prothrombin.
Drug it is contraindicated at disturbances of function - a liver and kidneys, at pregnancy.
Form of release: capsular on 0,25 and 0,5 g
See also Antikholesterinemichesky means .
Bibliography 3adionchenko V.S. and d river. Use of the Hungarian drug of Miscleronum (Clofibratum) for patients with atherosclerosis of coronal arteries and its influence on a hemostasis, lipidic and protein metabolism, Wenger, pharmakoter., Sq.m, page 87, 1973; Lobova N. M., B and in and N and M.*B. and Koropova G. I. Metabolic basis of lipotropic therapy of atherosclerosis, 'Cardiology, t. 14, No. 12, page 79, 1974, bibliogr.; Levy R. I. a. R i f-k i n g B. M. Lipid lowering drugs and hyperlipidaemia, Drugs, v. 6, p. 12, 1973, bibliogr.
A. H. Klimov.