CHONDROITINSULPHURIC ACIDS

From Big Medical Encyclopedia

CHONDROITINSULPHURIC ACIDS (a synonym chondroitin-sulfates) — group acid it glikozaminoglika-is new, molecules to-rykh are constructed of the alternating disakharidny links consisting from D-glucuronic (or L-iduronic) acid and the sulphated aminosugar D - ra-laktozamina. X. to. treat those glikozaminoglikana (see Mu co polysaccharides), molecules to-rykh most often contain covalently the connected proteinaceous component (box), i.e. to glikozaminoproteogli-kana, or just proteoglycans. The proteoglycans supporting X. to., are a part of intercellular substance of connecting fabric (see) vertebrate animals, including the person, besides, proteoglycans are found in skin, bone and cartilaginous fabrics, a vitreous and cornea of an eye, a vascular wall, tissues of heart and brain. B yole. value X. to., as well as other acid glikozaminoglikan, napr, hyaluronic acids (see), consists in their influence on a water salt metabolism (see) thanks to ability to connect water and cations, to regulate process of diffusion (see), and also participation in intercellular interactions.

Because chondroitinsulphuric to - you are viscous and substantially the hydrated polyanions, they interfere with compression of connecting fabric and play a role of a peculiar lubricant of joint surfaces (see Joints).

The main connective tissue cells producing X. to., fibroblasts are. Biosynthesis of polisakharidny chains of X. to. it is carried out with participation of a series of the high-specific glikoziltransfe-times and sulfotransferases (see the Transfer elements) which are localized in a cytoplasmic reticulum (see. Endoplasmic reticulum) and in Golgi's complex (see Golgi a complex). Accession of polisakharidny chains of X. to. to a proteinaceous component it is carried out through a so-called binding site.

Genetically caused disturbances of a catabolism of X. to. lead to accumulation not turned by X. to. in cells and to development heavy patol. the states relating to diseases of accumulation — mukopoli-

to sakharidoza (see).

Bibliography: Vidershayng, Ia. Biot

chemical bases of glikozidoz, M., 1980; Kochetkov N. K., etc. Chemistry of carbohydrates, M., 1967; Biochemistry of glycoproteins and proteoglycans, ed. by W. J. Len-narz, p. 267, N. Y — L.f 1980;

Complex carbohydrates of nervous tissue, ed. by R. U. Margolis a. R. K. Margolis, p. 45, 103, N. Y., 1979. G. Ya. Vidershayn.

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