From Big Medical Encyclopedia

CHLORPROTHIXENE (Chlorprothi-xenum; synonym: Chlorprothixeni hyd-rochloridum, Taractan, Truxal, etc.; joint venture. B) — neuroleptic. 2-Hlor-9-(3-dimet of laminopropi-l of Eden) - a tioksa of a nten the guide ro x l about ri d;

C18H18C1NS. HC1:

On a chemical structure chlorprothixene can be considered as a structural analog of aminazine (see), At to-rogo instead of a nitrogen atom in the central part of a tricyclic kernel aminazine has the carbon atom connected by a double bond to the same side chain as.

In an experiment chlorprothixene oppresses conditioned reflexes, lowers a physical activity, shows antagonism with Phenaminum and Apomorphinum on action on c. the N of page, strengthens effect of somnolent and narcotic substances, has antiemetic effect. In comparison with aminazine possesses more expressed and - adrenoceptor blocking and holinoblokiruyushchy activity. Chlorprothixene exerts rather weak impact on striopallidal system that together with the expressed holinoblokirukltsy effect is the reason of rather rare emergence of extrapyramidal frustration at its use.

On a wedge, to observations psychotropic activity of chlorprothixene is characterized by a combination of sedation to the expressed antipsychotic and timoanaleptichesky (antidepressive) action. Surpasses aminazine in sedative activity. On expressiveness of antipsychotic action concedes to Triphtazinum (see) and to a haloperidol (see).

Chlorprothixene is applied at the mental diseases which are followed by concern, fear, affective frustration including at circular and simple slow schizophrenia with psychopatholike and neurosis-like symptomatology, etc. Use also for treatment of mental diseases at somatic the weakened patients, especially advanced age when stopping of psychomotor excitement is necessary according to vital indications. Besides, chlorprothixene apply as a calmative at neurosises, sleep disorders (separately and in a combination to hypnotic drugs), a skin itch and in quality about-ti in emetic means.

Appoint usually inside, since a daily dose of 0,025 — 0,05 g and gradually increasing it by 0,025 — 0.05 g a day to 0,2 — 0,4 g, in some cases to 0,6 g a day. For stopping of acute psychomotor excitement nreparat appoint intramusculary 0,025 — 0,05 g (1 — 2 ml of 2,5% of solution). In tyazhe-

ly cases the single dose is increased to 0,1 — 0,15 g. At neurosises drug is appointed inside on 0,005 — 0,015 g by 3 — 4 times a day.

By-effects at therapy by chlorprothixene: drowsiness, decrease in the ABP, tachycardia, dizziness, dryness in a mouth, a hypomyotonia. The phenomena of parkinsonism and other extrapyramidal frustration are observed seldom.

Contraindications to use generally the same that for neuroleptics of fenotiazinovy group, including an alcoholic poisoning and hypnagogues, parkinsonism, etc.

Form of release: tablets (dragee) on 0,015 and 0,05 g; ampoules on 1 ml of 2,5% of solution. Storage: in the place protected from light.

See also Neuroleptics.

Bibliography: And in r at c to and y G. Ya. and N of piece at in and A. A. Treatment mentally sick, page 48, M., 1981; The Medicines used in psychiatry under the editorship of G. Ya. Avrutsky, page 123, M., 1980; Rajevski To. C. Pharmacology of neuroleptics, page 51, M., 1976.

K. S. Rayevsky.