HINOTsYD (Chinocidum; synonym of Qui-nocide; GFH; joint venture. B) — antimalarial means. 6-Metoksi-8-(4 aminopentyl) - aminoquinoline dihydrochloride; C15H20N3O*2HCl:
Orange-yellow crystal powder of bitter taste. *Очень we will easily dissolve in water. Let's difficult dissolve in 95% alcohol. It is hygroscopic; £ °pl 225 — 228 °; pier. weight (weight) 332,28.
Is a fabric shizontotsid concerning ectoglobular dli-telnosushchestvuyushchy forms (gipno-zoit) Plasmodium vivax and P. ovale and possesses gamontotsidny action concerning sexual forms of all types of plasmodiums, including drug resistant strains of P. falciparum (see Malaria, an etiology). The mechanism of action of Chinocidum on the specified forms of plasmodiums is connected with oppression of activity of mitochondrions in them.
It is well soaked up from went. - kish. a path and quickly collects in a blood plasma. In 24 hours after reception in plasma only traces of drug are found. An asset -
the nost of Chinocidum is caused by hl. obr. its metabolites, to-rye are quickly removed with urine.
Apply to the prevention of the remote recurrence of the malaria caused by R. vivax and P. ovale and also for prevention of the remote displays of malaria for the persons put high risk of infection with these forms of an infection at to-rykh a disease it was not diagnosed. Besides, Chinocidum is applied as gamontotsidny means to public chemoprophylaxis of malaria.
Appoint inside after food. The daily dose of drug is appointed in one-two receptions. To protivore-tsidivny treatment Chinocidum is applied after the end of treatment of acute displays of malaria and a parasitosis according to two schemes: during 10 (according to the scheme 1) or 14 (according to the scheme 2) days. Daily doses for adults: according to the scheme 1 — 0,03 g; according to the scheme 2 — 0,02 g. Daily doses for children according to the scheme 1: till 1 year — 0,0025 g, 1 — 2 years — 0,005 g, 2 — 4 years — 0,0075 g, 4 — 7 years — 0,01 g, 7 — 12 years — 0,015 g, 12 — 15 years — 0,02 g, are more senior than 15 years — 0,03 g; according to the scheme 2: till 1 year — 0,0015 g, 1 — 2 years — 0,0025 g, 2 — 4 years — 0,005 g,
4 — 7 years — 0,0075 g, 7 — 12 years — 0,01 g, 12 — 15 years — 0,015 g, are more senior than 15 years — 0,02 g. Treatment according to
the scheme 2 is usually appointed the weakened patient in a hospital. Prevention of the remote displays of the malaria caused by R. vivax and P. ovale is carried out according to the same scheme.
In the anti-epidemic purposes Chinocidum is applied at tropical malaria in the period of possible infection of mosquitoes (or just before its approach). At the same time he is appointed the adult in a daily dose of 0,03 g, to children — according to age, 3 days in a row after the end of treatment of acute manifestations (parasitosis) or during the holding preventive actions.
As side effects Chinocidum makes sick, a headache, cyanosis, sometimes — fever and signs of irritation of kidneys and a bladder that usually passes at drug withdrawal.
At persons with diseases of cardiovascular system, napr, at atherosclerosis, a koronarokardioskleroza, an idiopathic hypertensia, myocardial dystrophies, drug can cause pains in heart, negative dynamics of an ECG.
With insufficiency in erythrocytes of enzyme of the glyukozo-6-phosphate-dehydrogenase (G6PD) Chinocidum often causes an intravascular hemolysis in persons, to-ry is followed by abdominal pains and areas of podreberiya, and also jaundice, increase in the sizes of a liver, spleen, headaches, the general weakness, a haemoglobinuria, a proteinuria, a cylindruria. In such cases use of drug is immediately stopped. At massive hemolysis appoint glucocorticoids. Timely recognition of possible hemolitic effect of Chinocidum requires overseeing by the persons accepting this drug.
It is contraindicated at diseases of blood and bodies of a hemopoiesis, tendency to a granulocytopenia, rheumatism, a system lupus erythematosus, diseases of kidneys. It is impossible to appoint Chinocidum along with the quinine and other drugs having hemolitic effect or the oppressing influence on the hemopoietic system. It is appointed with care at suspicion to deficit of G6FD and at instructions in the anamnesis on intolerance of quinine, levomycetinum, streptocides and non-narcotic analgesics.
Form of release: tablets on
0,005 and 0,01 g. Storage: in well corked banks of dark glass.
See also P rotivomalyariyny means.
Bibliography: See bibliogr. to St. Quinine.
S. A. Rabinovich.