CHINIOFONUM (Chiniofonum; synonym: yatren, Chinosulfan, Iochinolum, Qui-noxyl, Yatrenum, etc.; GFH, joint venture. B) — synthetic chemotherapeutic means from group of derivatives 8 oxyquinolines. Mix 7 iodine - 8-OKSI-5 quinolinsulfoxyacids with hydrosodium carbonate in the ratio 3:1; C9H6IN04S + NaHC03:
Inodorous yellow powder. Let's dissolve in water with release of carbon dioxide gas. It is almost insoluble in ether and chloroform. Contains 25 — 26% of iodine.
On a chemical structure and a range of antimicrobic action it is close to Enteroseptolum. It is active concerning a dysenteric amoeba and some other protozoa, and also concerning gram-positive and gram-negative bacteria. At topical administration stimulates development of granulyatsionny fabric. After intake from went. - kish. a path it is soaked up only apprx. 10 — 15% of the entered dose in this connection in intestines drug collects in high concentration. At parenteral administration it is quickly soaked up in blood and removed through kidneys preferential in not changed look.
Apply hl. obr. at amoebic dysentery (see the Amebiasis), protozoan and ulcer colitis (see), and also as an antiseptic agent for treatment of purulent wounds (see Wounds, wounds), ulcers (see the Ulcer), burns (see) Etc.
At amoebic dysentery and colitis Chiniofonum is appointed usually inside the adult on 0,5 g by 3 times a day, within 8 — 10 days. If necessary the dose is increased to 3 g a day, and the cycle of treatment is repeated in 10 days. To children Chiniofonum is appointed according to the same scheme in I follow
shchy daily doses: at the age of
1 — 2 years — 0,1 g; 2 — 3 years — 0,15 g; 3 — 4 years — 0,2 g; 4 — 5 years — 0,25 g; 5 — 6 years — 0,3 g; 6 — 8 years — 0,45 g; 8 — 12 years — 0,6 g; 12 — 13 years — 0,7 g; 13 — 15 years — 1 g; 16 years are also more senior — 1,5 g
the Highest doses for adults inside: one-time 1 g, daily 3 g.
At colitis Chiniofonum can be applied in enemas (adult 200 ml of 1 — 2% of solution). As an antiseptic agent it is applied outwardly in the form of 0,5 — 3% of solutions, 5 — 10% of ointments and 10% of powders.
Side effect of drug is shown generally by a diarrhea. At prolonged use the optic neuritis can develop. Just as enterosepto Chiniofonum is contraindicated to l at diseases of the central and peripheral nervous system, damages of an optic nerve, hypersensitivity to iodine, and also at a hyperthyroidism and an acute renal failure.
Forms of release: powder and tablets on 0,25 g. Storage: in banks from orange glass with ground stoppers in the dry, protected from light place.
Bibliography: Clinical pharmacology,
under the editorship of V. V. Zakusov, page 555, M., 1978.
V. K. Muratov.