From Big Medical Encyclopedia

CARNOSINE (beta alanyl - L - a histidine) — the dipeptide which is a part of skeletal muscles of animals as well as its metilirovanny derivative — anserine. In skeletal muscles of the person it is found only To. in quantity apprx. 100 mg of % (on the wet weight of fabric). In cordial and unstriated muscles of the person trace quantities are found To.: tissue of a brain contains a homolog To. — gamma aminobutyrylhistidine (gomokarnozin).

At animals white muscles contain more To., than red. Distribution To. in a muscle not evenly: it is more of it in the places rich with nerve terminations. Contents To. sharply decreases at denervation of a muscle, and also at dystrophy of muscles as a result of any patol, process (e.g., at the progressing muscular dystrophy).

At a research of influence of dipeptides on exchange processes it is experimentally established that To. at presence creatine (see) provides preservation of fraction of labile phosphate on more high level. Keeping of mitochondrions of muscular tissue in the solution containing To. or anserine (see), provides in them an associativity of oxidation and phosphorylation.

Bibliography: Meshkova N. P. Dipeptides of skeletal muscles — carnosine and anserine, in book: Usp. biol, chemical, under the editorship of B. N. Stepanenko, t. 6, page 86, M., 1964; Severins. E. Distribution, turning into an organism and biological value of carnosine and anserine, in the same place, under the editorship of V. N. Orekhovich, t. 2, page 355, M., 1954; it, Biological role of natural dipeptides of skeletal muscles, Vestn. Mosk. un-that, it is gray. biol., No. 1, page 3, 1972, bibliogr.

N. P. Meshkova.