CARDIOTRASTUM (Cardiotrastum, GFH; synonym: Arteriodone, Diodonum, Diodrast, Jodopyracet, Joduron, Jodumbran, Leodrast, Neospekt, Nycotrast, Ombradil, Oparenol, Pelviran, Perjodal, Pyelosil, Savac, Umbradil etc.) — radiopaque substance (3,5-diiodpyridone-4 silt-1) - acetic to - you, beta and diethanolamine salt C 7 H 5 I 2 NO 3 - With 4 H 11 NO 2 :
White crystal powder, easily water soluble; contains 49,8% of iodine. Water solutions — transparent colourless or slightly yellowish liquids, pH 6,8 — 7,4.
To. apply at radiodiagnosis for contrasting of heart, blood vessels, a renal pelvis, ureters, a bladder, and also at a research of function of kidneys. At angiocardiography solutions, for excretory Urografinum — 35% solution use 50 and 70%. At a retrograde piyelografiya of 35% solution K. part with sterile isotonic solution of sodium chloride up to 15% of concentration. The amount of the entered solution depends on a technique of a research; average doses of 30 — 40 ml, a limit single dose — 1 ml on 1 kg of the weight inspected. Before introduction solutions K. heat to body temperature. For 1 — 2 day prior to a research carry out a sensitivity test of an organism to iodine by intravenous administration of 2 ml of 35% of solution K. In case of signs of hypersensitivity to iodine (a skin itch, a small tortoiseshell, cold, hypostasis of a throat, etc.) use of drug is contraindicated. Lack of reaction to a trial ampoule does not guarantee, however, against a hyperergy after introduction of the main amount of drug. Therefore during the carrying out a research it is necessary to have antihistaminic drugs for intravenous administration.
To. it is possible to use also for contrasting of an abdominal cavity (peritoneografiya), pleurae (plevrografiya), a pericardium. For fistulo-, bronkho-and metrosalpingografiya apply To. with the increased viscosity, the edge is reached by addition to it gelatin or carboxymethylcelluloses.
At introduction To. there can be a feeling of heat, dizziness, nausea, tachycardia, hypotonia, as a rule, these phenomena pass independently within the first hours after administration of drug. As well as other iodide drugs, To. can cause at angiocardiography thrombophlebitis in the place of its introduction, and also fibrinferments of vessels.
Drug it is contraindicated at the acute inflammatory and dystrophic diseases of a liver and kidneys which are followed by insufficiency of their function at sharply expressed general weakness, severe damage of a myocardium, the expressed cardiovascular insufficiency, active tuberculosis, a hyperthyroidism, and also the patient in old age.
Forms of release: 35 and 50% solutions in ampoules on 2 and 20 ml, 70% solution in ampoules on 2, 20 and 50 ml. Store at the room temperature in the place protected from light. At storage of 50 and 70% of solutions K. loss of crystals is possible. In these cases of an ampoule heat in water to t ° 40 — 50 °. If crystals are completely dissolved, solution absolutely transparent and during the cooling to t ° 37 ° crystals do not drop out again, drug is good for the use.
Due to smaller (in comparison with triyodsoderzhashchy drugs) efficiency and frequent side effect use To. it is limited.
See also Radiopaque substances .
Bibliography: Sergeyev P. V. X-ray contrast means, M., 1971, bibliogr.; In ark e R. Rontgenkontrastmittel, Lpz., 1970.
L. S. Rozenshtraukh.