From Big Medical Encyclopedia

CARCINOSARCOMA (Greek karkinos cancer, a crab + sarcoma) — the rare malignant tumor consisting of epithelial and connective tissue components. The term was offered by R. Virkhov in 1864.

Macroscopically the tumor represents polipovidny education on a thick leg, moderately dense consistence, rozovatozhelty or yellow-gray color. At microscopic research the epithelial component of a tumor most often has structure of planocellular cancer, is more rare transitional cell, low-differentiated or adenocarcinomas; the connective tissue component is presented by spindle-shaped and cellular sarcoma, sometimes a fibrosarcoma, is more rare leyomio-or a rhabdomyosarcoma. Extent of distribution and frequency of innidiation are various depending on localization of a tumor. Metastasizes either an epithelial, or connective tissue component, sometimes both are at the same time. Metastasises extend limfogenno.

The tumor meets preferential in an endometria, can arise in a neck of uterus, a vagina, a gullet, a throat, an easy, gall bladder, a stomach, a prostatic and thyroid gland. The wedge, a picture depends on localization. To. differs in the expressed zlokachestvennost and quickly leads to a lethal outcome.

Treatment operational. The chemotherapy is not effective. The possibility of use of hormonal and beam treatment is studied.

See also Cancer , Sarcoma .

Bibliography: Galankin V. N. and Livshits G. S. Kartsinosarkoma of a throat, Arkh. patol., t. 38, No. 12, page 58, 1976; P e in z and with M. G. and Nikolaev. O. Sluchay of a carcinosarcoma of a gullet, in the same place, t. 31, No. 12, page 59, 1969, bibliogr.; Brandt M. u. Marzotko F. Beitrag zum Karzinosarkom des Uterus, Zbl. allg. Path. path. Anat., Bd 121, S. 129, 1977, Bibliogr.; Lorenz G. Karzinosarkom der Callenblase, Zbl. Chir., Bd 99, S. 1658, 1974; Ludwigsen E. Endobronchial carcinosarcoma, Virchows Arch. Abt. A, Bd 373, S. 293, 1977, Bibliogr.; M a-n e s J. L. a. T and at 1 o r H. B. Carcinosarcoma and mixed mullerian tumors of the fallopian tube, Cancer (Philad.), v. 38, p. 1687, 1976; Matsusaka T., W a-tanabeH. EnjojiM. Pseudosarcoma and carcinosarcoma of the esophagus, ibid., v. 37, p. 1546, 1976.

H. H. Petrovichev.