From Big Medical Encyclopedia

CARBOCROMENUM (Carbocromenum; synonym: Intensainum, Intencordinum, karbokhromen, Chromonar, Intensacrom, joint venture. B) — anti-anginal means. 3 - beta Diethylaminoethyl) - 4-metil-7-karbetoksimetoksi-2-okso-(1,2-hromena) a hydrochloride, C 20 H 27 O 5 N-HCl:

Let's well dissolve in water, it is hygroscopic.

To. expands coronary vessels, increases rate of volume flow of a coronary blood-groove, improves supply of a myocardium with oxygen and promotes development of collateral circulation (especially at prolonged use). Can lower a tone of brain vessels. And the ABP level has no significant effect on heart rate. The mechanism of action To., apparently, it is connected with its ability to brake activity of phosphodiesterase that conducts to a delay of splitting of cyclic adenosinemonophosphate, and also with ability to normalizovyvat the level of nikotinamidny coenzymes in a myocardium.

To. apply for stopping of attacks of stenocardia and treatment hron, coronary insufficiency. At the stenocardia of rest which arose because of the stenosing coronarosclerosis To. it is almost inefficient.

Drug is appointed inside on 0,15 g by 3 times a day after food during 2 weeks — 1,5 months; in more hard cases appoint 0,15 g 4 times a day in the beginning, and after improvement of a state the dose is reduced to 0,075 g by 3 times a day. The effect of administration of drug is shown 10 — 14 days later after an initiation of treatment and keeps is long. At heavy attacks of stenocardia To. enter intramusculary or intravenously 0,04 g of 1 — 2 time a day; for intravenous administrations contents of an ampoule (powder) are dissolved in 4 — 10 ml of water for injections and entered slowly (within 3 — 5 min.).

At use of drug in some cases there can be a headache, the general weakness, nausea, vomiting; at bystry intravenous administration — retrosternal pains, weight in the head, feeling of heat. At prolonged use To. increase in activity of coagulant system of blood is possible.

To. it is contraindicated at a peptic ulcer of a stomach and duodenum, frequent aggravations hron, gastritis, diseases of a liver and kidneys with disturbance of their function.

Forms of release: tablets on 0,075 g, ampoules containing 0,04 g of the dry (lyophilized) drug which is dissolved in water for injections just before the use.

See also Anti-anginal means .

Bibliography: Vitolin R. O., Ki-menis A. A. and Peterson I. O. Coronarodilator means — Carbocromenum, Chemical - pharm, zhurn., t. 9, No. 11, page 57, 1975, bibliogr.

V. P. Fisenko.