BILITRASTUM

From Big Medical Encyclopedia

BILITRASTUM (Bilitrastum; Biliselectan, Bilitest, Bilopsyl, Bilospect, Choletrast, Feniodol, Iodobil, Pheniodolum, Priodax etc.) — a contrast agent. alpha Phenyl - beta (3,5-diiodine-4-oxyphenyl) - propionic acid; With 15 H 12 O 3 I 2  :

White or with a yellowish shade crystal powder, is water-insoluble; it is well dissolved in alkalis, ether, alcohol, in many other organic matters. Contains apprx. 52% of iodine.

Apply at the cholecystography only inside, an average single dose — 3 g. The dose can be raised to 4 — 5 g according to the weight of the patient. So-called techniques of saturation which allow introduction several high doses of drug are used.

Without decaying in a stomach, B. comes to a small bowel where it is soaked up in blood. Then through a portal vein a part of the entered dose comes to a liver from where as a part of bile passes into a gall bladder; a part, passing a liver, comes to kidneys.

The maximum concentration of drug in a gall bladder is observed usually in 13 — 14 hours after its reception. Bilious ways in most cases are not contrasted. More than 60% of B. which got into a liver and bilious ways are removed with urine during 2 — 3 days; other quantity — through a large intestine.

A technique of carrying out the cholecystography using B. — see. Cholecystography .

After B.'s use there can be a burning sensation, pains in a gall bladder, nausea, vomiting, sometimes a diarrhea. B. it is contraindicated at diseases of kidneys, an acute gastroenteritis, hypersensitivity to iodine.

Forms of release: powder and granules. Store in hermetically the corked ware from orange glass.

See also Radiopaque substances .

Bilitrastum radioactive — Bilitrastum, marked iodine-131. The method of receiving is based on reaction of isotopic exchange between sodium iodide-131 and pharmacopoeian

B. B. radioactive — the transparent colourless or slightly yellowish solution containing 2,5 — 8 mg/ml of the main substance; pH = 7,5 — 9,0, specific activity 0,2 — 1 mkyuri/ml, radiochemical impurity — to 5%, including sodium iodide-131 — no more than 3%; it is sterile, apirogenen. At a tag a radioiodine biological properties B. remain.

Apply to diagnosis of a functional condition of a liver and a gall bladder and scanning of a gall bladder. The functional research is conducted after introduction to radioactive B.'s vein in a dose 0,3 — 0,5 mkkyuri/kg with use of a method of graphic registration of content of drug in blood, a liver and a gall bladder on radiometric installations of type to UR.

Scanning of a gall bladder is made on an empty stomach through 1/2 — 3 hours after introduction 3 — 5 mkkyuri/kg radioactive B.

See also Radio isotope research .


Bibliography: Lindenbraten L. D. X-ray inspection of a liver and bilious ways, L., 1953, bibliogr.; Sergeyev P. V. X-ray contrast means, M., 1971, bibliogr.; In ark e R. Rontgenkontrastmittel, Lp7., 1970, Bibliogr.; Knoefel P. K. Radiopaque diagnostic agents, Springfield, 1961.

L. S. Rozenshtraukh; Η. F. Tarasov (medical I am glad.).

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