From Big Medical Encyclopedia

BERING PHENOMENON (E. Behring) — summation of toxic influence at repeated introductions of sublethal doses of bacterial toxins, at a cut an animal perishes before receives a half of the minimum lethal dose of exotoxin. The total amount of the bacterial exotoxin entered to an animal by fractional doses is many times less than DLM at single introduction. The phenomenon was described in 1893 by the German scientist E. Bering. B. f. it is shown at introduction of fractional doses of botulinic, diphtheritic, tetanic exotoxins, and also exotoxins of activators of a mephitic gangrene. B.'s manifestations f. are established also at introduction to mice of small doses (1/100 — 1/1000 DLM) an influenza virus and a rhabdovirus: animals perish from the specific infection caused by doses of a virus by 10 — 100 times smaller than DLM at single introduction.

Mechanism of development of B. f. it is not known. Sensitization of animals to bacterial exotoxins and viruses at frequent introduction of small doses by it has no feedforward with the size of the entered fractional dose and with reaction of the cells developing specific antibodies. However it is established that at introduction of fractional doses of bacterial exotoxins or viruses development of intoxication or infection happens to an interval of 15 — 60 min. quicker, than at introduction of the same bucketed doses at 24 o'clock.

According to P.F. Zdrodovsky (1950), during an incubation interval at infectious diseases the person also has a summation of stimuli on type B. f. at the expense of the products allocated by the activator breeding in an organism owing to what the clinical picture of a disease develops.

Bibliography: Zdrodovsky P. F. Problems of an infection, immunity and allergy, page 104, M., 1969; Kravchenko A. T. and Privalova L. I. Infectious allergy, Shurn. mikr., epid, and immun., No. 4, page 3, 1966; Kravchenko A. T. and With e - P. M kretta. Change of reactivity of an organism in the course of an infection and immunization by viruses, in the same place, ΛΙ> 1, page 16, 1953; Matveev K. I. Botulism, page 179, M., 1959; Swordsmen I. I. Nevospriimchivost in infectious diseases, page 454, M., 1947; Behring E. Allge-meine Therapie der Infectionskrankheiten, Bd 1, T. 2, S. 1051, B. — Wien, 1900.

A. T. Kravchenko.