BENZOTEPHUM (Benzotephum, A-16; joint venture. And) — antineoplastic drug. N-benzoyl-N', N', NN- dietilentriamid phosphoric to - you, C 11 H 14 N 3 PO 2 :
Fine-crystalline powder, water soluble. Melts at t ° 150 — 152 °. B. treats cytostatic drugs which mechanism of action consists in oppression of cell fission in connection with dysfunction of macromolecules (proteins, nucleic acids). Ying volume is offered pharmacology and toxicology of M3 of USSR.
B. apply in the same cases, as Thiophosphamidum, in particular at cancer of an ovary and a breast cancer. Drug is capable to cause regression of a tumor and remission lasting from 2 to 8 months
of B. appoint intravenously on 24 mg in 20 ml of isotonic solution of sodium chloride 3 times a week (sometimes more rare), to a course 15 — the 20th injection. At cancer pleurisy and ascites the drug is administered in the same doses in a cavity after evacuation of exudate, repeated courses are appointed in 1,5 — 2 months. At B.'s treatment systematic hematologic control is necessary. At overdose or hypersensitivity of patients to B. there can be a considerable leukopenia, thrombocytopenia and even a pancytopenia. In rare instances at patients nausea and vomiting is observed. At sharp reduction of number of leukocytes and thrombocytes B.'s introduction is stopped and appoint hemotransfusion or its components and means, stimulating a hemogenesis. Use of drug is contraindicated at sharp exhaustion of an organism, in end-stages of a disease, at the expressed leukopenia and anemia, and also at serious associated diseases (active tuberculosis, parenchymatous hepatitis, nephrite etc.).
Forms of release: the soldered ampoules or hermetically the corked bottles containing 0,024 g of drug. Store in the cool, protected from light place.
See also Antineoplastic means .
Karachunsky M. S. Therapeutic effectiveness petrolthat-fa. Doctor, business, L» 4, page 129, 1964; Palchikova R. P. Results of treatment of patients with malignant .novoobrazovaniye drug beneotsf, in the same place, No. 12, page 117, 1962; Peysakhovich I. M., Sologub P. Ya. nprotsenkol. Antineoplastic action N-beyazoil-N', N', N", Ndietyalentriamid of phosphoric acid, in the same place, L «12, page 1249, 1958.
V. A. Chernov.