ARMINUM (Arminum; joint venture. And) — antikholinesterazny substance. Ethyl para-nitrophenyl ether ethylphosphonew to - you, C 10 H 14 O 5 PN:
Liquid of yellow color, is not enough rastvorim in water, well a rastvorim in organic solvents.
On antikholinesterazny activity And. surpasses prozerin (see), pirofos (see), Phosphacolum (see). Drug has also direct cholinomimetic and adrenomimetichesky effect (see. Adrenomimetichesky means , Cholinomimetic substances ).
Apply And. as miotic and protivoglaukomny means; in certain cases it surpasses in efficiency Pilocarpinum (see). Drug appoint in the form of eye drops in concentration 1: 10 000 — 1: 20 000 (0,01 — 0,005% solution) on 2 drops 2 — 3 times a day. After an instillation And. it is necessary to press for 2 — 3 min. a finger area of a dacryocyst to prevent hit of solution to the lacrimal canal.
Form of release: 0,01% and 0,005% aqueous solution (eye drops) in bottles on 10 ml. Keep under the lock in the dry dark place.
See also Antikholinesterazny means .
Bibliography: Aluf M. A. To pharmacology of Arminum, Pharm. and toksikol., t. 18, No. 2, page 21, 1955; Vasenin A. P. Studying of comparative action of Pilocarpinum and Arminum at glaucoma. Oftalm. zhurn., No. 4, page 306, 1965. Chemistry and use of organophosphorous connections, under the editorship of A. E. Arbuzov, page 555, etc., M., 1962.
I. V. Zaikonnikova.