From Big Medical Encyclopedia

ARGYROSIS (argyrosis; grech, argyros silver + - ösis; synonym argiriya) — pigmentation (brown and black-gray color) of skin, mucous membranes, internals, eyes in connection with deposits of silver in them. And. arises at working silver mines, at the persons who are engaged in preparation of a lyapis, silver varnish, silvering of radio components etc. and also at the long use with the medical purpose of drugs of silver (silver nitrate). Distinguish the general and local And. At the general And. adjournment of silver in skin, mucous membranes, internals is observed; at local there is a pigmentation only of separate body (e.g., eyes).

And. skin it is characterized by adjournment of granules of silver of hl. obr. in basal membranes of sweat glands and in a derma, directly under epidermis, in connective tissue covers of sebaceous glands and hair follicles, in walls of blood vessels, in nerves and in the muscles raising a hair. In mucous: covers of an oral cavity, stomach, intestines, mezenterialny limf, nodes, a spleen of a particle of silver find preferential in walls of vessels and in connective tissue layers.

At And. kidneys adjournment of granules of silver on the course of basal membranes of capillaries of balls and uric tubules (especially collective tubules), and also in apical departments of an epithelium of gyrose and direct tubules and in stro me body is observed; in a liver of a granule of silver are localized almost only in walls of interlobulyarny branches of a portal vein, in the connecting fabric surrounding them and also in kupferovsky cells. At And. testicles of a particle of silver find in interlobular connecting fabric, and also on the course of basal membranes of deferent ducts. And. an eye is characterized by adjournment of granules of silver in a conjunctiva and a descemete cover.

Under a microscope of adjournment of silver in fabrics look in the form of small dark brown or black granules. A research of microscopic sections at And. in a dark field of sight or after processing by their physical developer allows to reveal considerably bigger quantity of particles of silver, than at usual microscopy. Particles of silver usually do not cause reactive processes from surrounding fabrics and can decrease and even to disappear from walls of vessels, capillaries owing to their allocation with urine, then, etc. Deposits of granules of silver in connecting fabric usually remain for the rest of life. Clinically And. can proceed asymptomatically, but in some cases there are manifestations hron, intoxications salts silver (see).

Bibliography: A. I apricots. Fundamentals of the general pathological anatomy, page 136, M., 1949; Lever U. F. Gistopatologiya of skin, the lane with English, page 169, M., 1958, bibliogr.; Fuchs U. u. Franz H. Präparativ erzielte Silberanreicherung bei experimenteller Argyrose, Exp. Pathol., Bd 5, S. 163, 1971, Bibliogr.; Handbuch der speziellen pathologischen Anatomie und Histologie, hrsg. v. F. Henke u. O. Lubarsch, Bd 10, S. 50, B., 1930, Bibliogr.; Prose P h. H. An electron microscopic study of human generalized argyria, Amer. J. Path., v. 42, p. 293, 1963.

M. S. Tolgskaya, A. A. Chumakov.