APROPHENE (Aprophenum; synonym Aprofenum; GFH, joint venture. B) — cholinolytic means. β-diethylaminoethyl ether 1,1 diphenyl of propionic acid hydrochloride:
White crystal powder, we will easily dissolve in water and alcohol.
And., like other drugs of this group, exerts the oppressing impact on cholinereactive systems. Along with cholinolytic action And. causes spasmolytic myotropic effect: reduces a tone of smooth muscles of internals (except for a myometrium)
and expands vessels. On influence on coronary vessels And. surpasses papaverine (see).
And. apply at the diseases which are followed by a spasm of abdominal organs (a spastic colitis, cholecystitis, hepatic and renal colic, a peptic ulcer of a stomach and duodenum), and also a vasospasm (stenocardia, an endarteritis, etc.). Thanks to property A. to raise a tone and to strengthen reductions of a pregnant and nonpregnant uterus it apply in obstetric practice to stimulation of patrimonial activity. And. it is quickly soaked up from went. - kish. a path, but is more effective at hypodermic and intramuscular introduction. Drug is appointed inside after food on 0,025 g by 2 — 4 times a day, subcutaneously and intramusculary on 0,5 — 1 ml of 1% of solution. For acceleration of childbirth it is also possible to enter into a neck of uterus 1 ml of 1% of solution of aprophene. The highest doses inside: one-time — 0,03 g, daily — 0,1 g; subcutaneously and intramusculary: one-time — 0,02 g, daily — 0,06 g. A course of treatment — 10 — 15 days.
Forms of release: powder and tablets on 0,025 g, 1% solution in ampoules on 1 ml. Keep in the place protected from light in well corked container.
See also Cholinolytic substances .
Bibliography: Mashkovsky M. D. Pharmaceuticals, p.1, page 200, M., 1972.
S. S. Liberman.