From Big Medical Encyclopedia

ANTIVIRAL MEANS — the biological and chemical drugs interfering emergence and development of the diseases caused by viruses.

Among P. pages distinguish the drugs used for prevention and for therapy of viral infections.

Carry the live and inactivated (killed) vaccines (see) causing development of the immunity remaining a long time at introduction to an organism to preventive drugs. Use of a number of virus vaccines was successful, e.g., for prevention of such diseases as smallpox, poliomyelitis, measles, yellow fever. Immunoglobulins (see) and interferon belong to the prophylactics providing short-term protection of an organism (see). The mechanism of effect of immunoglobulins (antibodies) and interferon consists in ensuring anti-virus protection of cells which were not struck with a virus prior to use of these drugs yet. In this case their ability to prevent a viral infection is used.

Immunoglobulins, interferon and chemotherapeutic drugs, i.e. those means which can change process of a viral disease belong to therapeutic P. of page, leading to its termination.

Difficulty of therapy of viral diseases is caused by the fact that the virus is an obligate intracellular parasite, all development cycle to-rogo proceeds in cells and depends on cellular metabolism. P.'s search by the village with therapeutic effect is directed to research of drugs which have preferential inhibiting effect on a reproduction of a virus with the minimum influence on synthesis of macromolecules of a cell. The arsenal of such means is small. Connections from classes of thiosemicarbazones (Methisazonum), adamantylmethylamine (amantadin and Remantadinum), abnormal nucleosides — Kerecidum (idoksuridin), etc. belong to the most widespread chemotherapeutic drugs used for therapy of viral diseases. In an experiment antiviral action of some antibiotics is shown.

I. G. Balangding.