From Big Medical Encyclopedia

AMBENONIUM CHLORIDE (Oxazylum; synonym: Ambenonii chloriclum, Ambestigminum chloride, Mysuran, Mytelase chloride etc.; GFH, joint venture. A) — antikholinesterazny means. N, the N-bis (2 diethylaminoethyl) - an oksamid encore (ortho-chlorbenzyl chloride); With 28 H 42 With 14 N 4 O 2 • With 2 H 5 OH:

White crystal powder, easily water soluble, is hygroscopic; pier. weight 654,6; t pl 195 — 205 °.

The lake reversibly blocks true cholinesterase and is only insignificant — false. Duration of action — apprx. 6 — 7 hours, residual effect can longer remain. O.'s action develops in 1,5 — 2 hours after intake. In an experiment on animals eliminates the neuromuscular block caused by not depolarizing kurarepodobny means.

Apply at a myasthenia, motive disturbances in the recovery period of poliomyelitis, after the postponed meningitis, encephalitis, injuries of a brain, at a flaccid paralysis of a facial nerve. Appoint inside after food, at a myasthenia in an initiation of treatment the adult — in a dose of 0,005 g, then increase a dose, adding 0,001 g a day and watching efficiency of treatment and portability. Effective single doses — from 0,002 to 0,025 g (on average 0,01 g). In view of danger of cumulation of a dose and frequency of reception is selected strictly individually, taking into account the speed of approach and duration of action. At treatment of motive disturbances after O.'s poliomyelitis apply in a complex with others to lay down. actions (to lay down. physical culture, physical therapy) in single doses for children of 1 — 2 years — 0,001 — 0,002 g; 2 — 5 years - 0,002 — 0,003 g; 6 — 10 years — 0,003 — 0,005 g; 11 — 14 years — 0,005 — 0,007 g; 14 years — 0,007 — 0,01 g of 1 times in 2 — 3 days are more senior. The course of treatment consists of 15 — 20 receptions. Repeated courses are conducted in 2 — 3 months. At other motive pathology (paresis, paralyzes, muscular weakness) doses and frequency of administrations of drug make at adult 0,005 g 2 — 3 times a day, children up to 10 years — at the rate of 0,001 g for a year have lives in days in 2 — 3 receptions. The highest doses for adults inside: one-time — 0,025 g, daily — 0,05 g.

By-effects same, as at reception of other antikholinesterazny means (hypersalivation, nausea, a diarrhea, increase of an urination, twitching of skeletal muscles, etc.).

It is contraindicated at epilepsy, hyperkinesias, bronchial asthma and stenocardia.

Form of release: tablets on 0,001, 0,005 and 0,01 g. Store in the place protected from light.

SI. also Antikholinesterazny means .

Bibliography: Ginevets G. V. Experience of use of an ambenonium chloride at speech frustration, in book: Nevrol, and psikhiat., under red, Ya. V. Pishelya, century 1, page 89, Kiev, 1971; JI about z and V. S N. Comparative clinical assessment of antikholinesterazny drugs, in book: Myasthenic frustration, under the editorship of N. I. Grashchenkov. page 233, M., 1965.

B. A. Medvedev.