From Big Medical Encyclopedia

ACID RESISTING BACTERIA — bacteria steady against acids, alkalis and alcohols; slowly perceiving aniline paints, gram-positive; painted in pink color by Tsil's method — Nelsena. Not acid resisting individuals are painted at the same time in addition in blue color (see. Tsilya-Nelsena method ). After impact on them acids and alkalis, unlike other microorganisms, do not lose viability. This property is caused by their special chemical structure — the high content of the lipidic connections which are a part of difficult lipoproteidny, lipopolisakharidny, liponukleoproteidny complexes and high-molecular fat to - t (mikolovy and ftionovy), and also features physical. structures of protoplasm. In the mechanism of acid resistance the chemical structure of the surface layer of a cell formed by a large number of lipids, proteins and polysaccharides plays a role; the partial destruction of a cell wall connected with loss of lipids and mikolovy to - you, leads to loss of acid resistance. The typical representative To. — Mycobacterium tuberculosis has wide polymorphism, forming along with a usual acid resisting rod form granular options, not acid resisting sticks, the filtered forms, huge branchy structures with huge rhabdoid protrusions and kolboobrazny swellings that allowed to carry it to a sort of mycobacteria. Pathogenic cultures more strictly kislotoustoychiva, than saprophytes, and grow on mediums more slowly; their certain representatives (M. of leprae) do not grow on mediums at all and do not infect in an experiment of animals.

See also Leprosy, etiology ; Mycobacteria ; Tuberculosis, etiology .

Bibliography: Krasilnikov N. A. Actinomycetes are antagonists and antibiotic substances, M. — L., 1950, bibliogr.; Bergey’s manual of determinative bacteriology, ed. by R. E. Buchanan a. N. E. Gibbons, Baltimore, 1975, bibliogr.; M u-rohashi T. YoshidaK. Biological significance of acid-fastness of mycobacteria, Ann. N. Y. Acad. Sci., v. 154, p. 58, 1968.

T. B. Yablokova.