ACIDOPHILIA (Latin acidus acid + grech, philia tendency; synonym: oxyphilia, eosinophilia, fuchsinophilia) — tendency of protoplasm of cells and fibrous structures to be painted by such acid dyes as eosine, acid fuksinony the Term «acidophilia» was offered by Ehrlich (R. of Ehrlich) there is a founder of the chemical theory of coloring according to which preferential adsorption of acid dyes is defined by alkaline properties of fabric structures. A concept about And. along with basophilia (see) was widely adopted in the histologic equipment, pathological anatomy, hematology, oncology, cytology, etc. In hematology ability of fabrics to be painted by acid or main dyes is used for a differentiation of blood cells (eosinophilic granularity of leukocytes).
The peculiar new growths of ferruterous bodies (thyroid, parathyroid, parotid, salivary and other glands) consisting of large cells with acidophilic protoplasm and designated by the term are known oncocytoma (see). Separate oxyphilic cells quite often are found in tumors of a thyroid gland (Gyurtle's cell — Askanazi). Acquisition of oxyphilic properties by fabric structures in the conditions of pathology is qualified as acidophilic dystrophy — a kind of the proteinaceous dystrophy caused by decrease in cytoplasm of content of RNA. Such is And. nervous cells, connected with an anoxia and toxic influences, and also And. hepatocytes at a number of viral diseases (an infectious disease, an infectious mononucleosis, yellow fever). At partial coagulation of protoplasm there is a formation around a kernel acidophilic glybok (Mallori's little bodies), at a necrosis of separate cells there are intensively eosinophilic spherical educations — Kaunsilmen's little bodies. Fuchsinophil russelevsky little bodies in an atrofichny mucous membrane of a stomach at pernicious anemia have a similar origin and in granulyatsionny fabric at a rhinoscleroma owing to dystrophy of plasmocytes.
See also Histologic methods of a research .
Bibliography: Strukov A. I. Pathological anatomy, M., 1971.
N. K. Permyakov.