From Big Medical Encyclopedia

ACHLORHYDRIA (achlorhydria; grech, and - otritsa. + chloros green + hydör water) — absence free salt to - you in gastric contents. In clinic the term «anaciditas» as a synonym is quite often used And. Actually it is not absolutely correct since the gastric secret always happens acid.

Most of modern writers divides I. P. Pavlov's idea that the gastric juice always has constant concentration salt to - you: 160 mekv/l [J. Horeysi, 1967; L. Demling] or 143 mekv/l [A. Lambling and soavt., 1960].

Fluctuations of acidity of gastric contents and on an empty stomach, and after trial irritants are defined by a ratio of two main components: acid and alkaline. The acid component of secretion is a product of activity of obkladochny cells which allocate salt to - that. The alkaline component is a product of mucous glands of a stomach and represents slime in colloidal suspension of bicarbonates and neutral chlorides. At dominance of an acid component it is found free salt to - that; otherwise deficit salt to - you develops. Not only the curve free salt to - you, but also a possible curve of deficit has diagnostic value.

The etiology

the Achlorhydria can be a consequence of profound structural changes of the ferruterous device of a stomach owing to which obkladochny cells stop secretory activity. The greatest possible deficit salt to - you make 40 — 60 caption, units [A. Lambling and soavt., 1960; E. Hafter, 1962]. All gastric secretion is presented then by an alkaline component. In such cases speak about true And. — * absolute, or cellular.

Lamblen and Bernier (A. Lambling, J. Bernier, 1.958) allocate so-called relative, or chemical, And., when at incomplete oppression of the secretory device of a stomach obkladochny cells in response to an irritant allocate salt to - that in small amounts. Therefore free salt to - that can not be found.

True And. is always display of any disease (e.g., hron, gastritis, Pernicious anemia), relative And. can occur at healthy people as manifestation of typological features of nervous control of operation of the ferruterous device of a stomach.

Clinical picture

In most cases And. is followed by the dispeptic phenomena after food (weight in an anticardium, feeling of a raspiraniye, nausea).

The diagnosis

the Diagnosis is based on results of fractional sounding, measurement of pH of a gastric juice after the double and maximum histamine test, a morphological research of biopsy material.

Forecast depends on a cause of illness.


Treatment consists in elimination of a basic disease, use of clinical nutrition, purpose of extractives, periodic appointment salt to - you, drugs of a pancreas, vitamin B 1 and enzymes.

See also Stomach .

Bibliography: Belousov A. S. Sketches of functional diagnosis of diseases of a gullet and stomach, M., 1969; Vasilenko V. of X., Golubeva S. V. and P. I. K Kor-zhukova to diagnosis of an achlorhydria, Klin, medical, t. 49, No. 6, page 17, 1971; Linar E. Yu. Kisloto-obrazovatelnaya function of a stomach is normal also pathologies, Riga, 1968, bibliogr.; F and sh z about n-R y with with Yu. I. Modern methods of a research of gastric secretion, page 80, JI., 1972; D e sh-1 i n g L. Bestimmung der Magensäure, Dt sch. med. Wschr., S. 1682, 1965; L a m-bling A., Bernier J. - J. etBadoz-Lambling J. L’ explorati on fonction-nelle de l’estomac, Arch. Mal. Appar. dig., t. 49, p. 1074, 1960.

A. C. Belousov.