From Big Medical Encyclopedia

ACETYLDIGITOXIN (Acetyldigitoxinum; synonym: Acedoxin, Acylanid) — cardiac glycoside. Receive at enzymatic eliminating of glucose from Digilanidum And — a genuinical glycoside woolly foxgloves (see):

On biological activity and pharmacological properties A. it is close to to digitoxin (see). Differs from the last in more bystry elimination (a daily quota of allocation And. makes 10%, digitoxin — 7% of the maximum therapeutic dose) and kumulirut less. And. it is well soaked up in went. - kish. a path (to 80%), however it is less strong, than digitoxin, contacts a sarcoplasmic reticulum of a myocardium. And. is less active, than digitoxin, has less expressed vagotropic effect, but is better transferred by patients.

Use drug at hron, heart failure. In the first two days And. appoint inside 0,4 — 0,8 mg or (for the purpose of acceleration of cardiotonic effect) intravenously on 2 — 4 ml of 0,01% of solution a day. On reaching therapeutic effect immediately pass to maintenance doses — 1 — 2 ml of 0,01% of solution intravenously or 0,1 — 0,3 mg inside.

Caused And. the same side effects, as at use of digitoxin.

And. it is contraindicated at the expressed bradycardia, a total atrioventricular block, especially at emergence of a syndrome of Adams — Stokes — Morganyi, at increase of attacks of stenocardia.

Forms of release: tablets on 0,2 mg and 0,01% solution in ampoules on 2 ml.

See also Cardiac glycosides .

Bibliography: Mashkovsky M. D. Pharmaceuticals, p.1, page 314, M., 1972; The Foxglove, under the editorship of N. Ya. Itskovai of A. D. Turova, page 123, M., 1954, bibliogr.; Shvets F. A pharmacodynamics of drugs, the lane with slovatsk., t. 2, Bratislava, 1971; Augsberger A. Quantitatives zur Therapie mit Herzglykosiden, Klin. Wschr., S. 945, 1954, Bibliogr.; Stoll A. The cardiac glycosides, L., 1937; Stoll A. u. R e n z J. Herzglykoside der Digitalis ferruginea, Helv. chim. Acta, Bd 35, S. 1310, 1952.

V. V. Gatsura.