From Big Medical Encyclopedia

ACETONURIA (acetone + grech, wetting uron) — the increased allocation with urine of acetone. Acetone (see) is nonthreshold substance, and small increase in its concentration in blood is followed And. The healthy person allocates with urine no more than 0,01 — 0,03 g of acetone a day. And. accompanies a giperketonemiya and it is observed at many morbid conditions, being a consequence acetonemias (see). Most typically for And. allocation with urine ketone bodies (see), napr, β-hydroxy-butyric and acetoacetic acids at a dekompensirovanny diabetes mellitus. At the same time there is as the strengthened formation of ketone bodies in a liver, and a disturbance of their use at decrease in oxidation of metabolites of a lipometabolism in a tricarbonic acid cycle (see. Tricarboxylic acids cycle ). And. also it is observed at periodic atsetonemichesky vomiting, a number of infectious diseases, after operative measures, at injuries of a skull, a thyrotoxicosis, a renal glycosuria, starvation, unilateral bezuglevodisty food, etc. At children And. as the result of a giperketonemiya develops quicker at errors in food.

Diagnostic value A. has at a diabetes mellitus and atsetonemichesky vomiting. Acetone in urine decides by means of tests on Sodium nitroprussidum and it is found together with acetoacetic acid (see. Nitroprussiate reaction ),

Bibliography: Biochemical methods of a research in clinic, under the editorship of A.A. Pokrovsky, page 279, M., 1969; e N e with S. G. Diabetes mellitus, page 12, M., 1949; Ferdman D. L. Biochemistry, page 527, M., 1966.

Yu. A. Knyazev.